Volume : V, Issue : XI, November - 2015
COMPARISON OF CLINICAL EFFICACY AND SAFETY OF RAMOSETRON WITH ONDANSETRON FOR THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING SURGERY UNDER SPINAL ANESTHESIA
Dr Pankaja R, Dr Anil Kumar M R, Dr N S Shashi Kumar
Abstract :
<p>&nbsp;Background and Objectives of the Study Nausea and vomiting are the most common distressing symptom in the post operative period. This study was undertaken to evaluate the clinical efficacy and safety of prophylactic use of intravenous Ramosetron 0.3mg with intravenous Ondansetron 4mg in preventing Post Operative Nausea and Vomiting (PONV) after surgery under Spinal anesthesia and to determine the incidence of adverse effects with Ramosetron and Ondansetron. Materials and Methods: In this randomized, open&ndash;label study, 80 patients (age, 18&ndash;60 years) of ASA I&ndash;II, received intravenous Ramosetron 0.3mg or Ondansetron 4mg (n = 40 of each) immediately before induction of anesthesia. Postoperatively the incidences of nausea, vomiting, retching and safety assessments were performed at 0, 2, 6, 24 and 48hour during the first 48hour after surgery. Results: The percentage of patients who had complete response was 80% (32/40) with Ramosetron and 37.5% (15/40) with Ondansetron (P &lt; 0.001). The proportion of patients requiring rescue antiemetics was significantly lower with Ramosetron (5%) when compared with the Ondansetron group (15%) during the 48 hr after surgery (P&lt;0.05). There was no significant difference in the incidence of side effects between the two groups. Conclusion: Ramosetron (0.3mg) was more effective than Ondansetron (4mg) in preventing PONV in patients undergoing surgery under Spinal anesthesia.</p>
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DOI : 10.36106/ijar
Cite This Article:
DR Pankaja R, DR Anil Kumar M R, DR N S Shashi Kumar / COMPARISON OF CLINICAL EFFICACY AND SAFETY OF RAMOSETRON WITH ONDANSETRON FOR THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING SURGERY UNDER SPINAL ANESTHESIA / Indian Journal of Applied Research, Vol.5, Issue : 11 November 2015
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DR Pankaja R, DR Anil Kumar M R, DR N S Shashi Kumar / COMPARISON OF CLINICAL EFFICACY AND SAFETY OF RAMOSETRON WITH ONDANSETRON FOR THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING SURGERY UNDER SPINAL ANESTHESIA / Indian Journal of Applied Research, Vol.5, Issue : 11 November 2015
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