COMPARISON OF DEXMEDETOMIDINE 2 MCG WITH CLONIDINE 50 MCG ADDING TO 12.5 MG OF 0.5% HEAVY BUPIVACAINE FOR SPINAL ANAESTHESIA IN LOWER ABDOMINAL SURGERIES.

Dr.Murali Prabhakar; Dr. Sandeep.G.B

Volume : V, Issue : II, February - 2015

COMPARISON OF DEXMEDETOMIDINE 2 MCG WITH CLONIDINE 50 MCG ADDING TO 12.5 MG OF 0.5% HEAVY BUPIVACAINE FOR SPINAL ANAESTHESIA IN LOWER ABDOMINAL SURGERIES.

Dr. Murali Prabhakar, Dr. Sandeep. G. B

Abstract :

Context: Comparison of Dexmedetomidine 2 MCG with Clonidine 50 MCG adding to 12.5MG of 0.5% Heavy Bupivacaine for Spinal Anaesthesia in Lower Abdominal Surgeries. AIM: aim of our study was to compare the Dexmedetomidine 2 MCG with Clonidine 50 MCG adding to 12.5MG of 0.5% Heavy Bupivacaine for Spinal Anaesthesia in Lower Abdominal Surgeries. Settings and Design: The present prospective study was carried out in a territory care Teaching Hospital. A total of 60 patients of ASA I and II undergoing lower abdominal Surgery Under spinal Anaesthesia was enrolled in this study. Patients were randomly divided in to two Groups, Group C (Clondine group) and Group D (Dexmedetomidine) with 33 patients in each group. Materials and Methods: Patients in group C received 2.5ml of 0.5% hyperbaric Bupivacaine with 50 μg of Clonidine. Patients in group D received 2.5 ml of 0.5% hyperbaric Bupivacaine with 2 μg of Dexmedetomidine. Statistical Analysis Used: Data were Analyzed using MS Excel software and SPSS software for determining the statistical significance. Analysis of Variance was used to study the significance of mean of various study parameters between the two groups. Student’s t test was used to compare the two groups on mean values of various parameters. The p–value <0.05 is considered significant. Results: In our study, patients remained hemodynamically stable in both Dexmedetomidine and Clonidine groups. Patients in Clonidine group had a greater fall in heart rates than in Dexmedetomidine groups, and the difference was statistically significant. There was no much fall in blood pressure and heart rate when compared to the baseline values. Conclusion: Addition of Dexmedetomidine 2μg to 0.5% heavy Bupivacaine intrathecally produced faster onset of sensory blockade, longer duration of analgesia and motor blockade and better haemodynamic stability than Clonidine 50μg