COMPARISON OF EFFICACY OF ORAL PREGABALIN VERSUS GABAPENTIN IN THE ATTENUATION OF HEMODYNAMIC STRESS RESPONSE IN PATIENTS UNDER GENERAL ANAESTHESIA: A PROSPECTIVE RANDOMIZED DOUBLE BLIND STUDY.

Dr Ramya Manjunath; Dr Shanta Hungund; Dr Thilakchand KR

Volume : IX, Issue : II, February - 2019

COMPARISON OF EFFICACY OF ORAL PREGABALIN VERSUS GABAPENTIN IN THE ATTENUATION OF HEMODYNAMIC STRESS RESPONSE IN PATIENTS UNDER GENERAL ANAESTHESIA: A PROSPECTIVE RANDOMIZED DOUBLE BLIND STUDY.

Dr Ramya Manjunath, Dr Shanta Hungund, Dr Thilakchand Kr

Abstract :

INTRODUCTION: Laryngoscopy and tracheal intubation induces changes in circulating catecholamine levels significantly. This can result in detrimental effects including myocardial ischemia, infarction, cardiac dysrhythmia, premature ventricular complexes, cardiac failure, raised ICP and intracranial haemorrhage especially in high risk patients. Pregabalin and Gabapentin are two agents that have been used to prevent this pressor response. So, the present study is undertaken to compare the efficacy of oral Pregabalin and Gabapentin in attenuating hemodynamic response to laryngoscopy and intubation. OBJECTIVES: The present study compares the efficacy of oral Pregabalin and Gabapentin in attenuating hemodynamic response to laryngoscopy and intubation. Haemodynamic responses were compared in both the groups by measuring at different time points: 1. Heart Rate (HR) 2. Mean Arterial Pressure (MAP) METHODS: After institutional ethical committee clearance, a prospective randomized control study was conducted. A total of 80 patients of ASA grade 1 and 2 of age groups 18–60 years undergoing elective surgeries under general anaesthesia were included. Group P (n=40), was the pregabalin group and Group G (n=40), was the gabapentin group. Patients in both groups received oral pregabalin and gabapentin respectively one hour prior to surgery. Patients underwent general anaesthesia with induction of propofol 2mg/kg IV and muscle relaxation with succinyl choline 2mg/kg IV. The airways were secured with endotracheal intubation. Anaesthesia was maintained with Sevoflurane 1%. RESULTS: Statistical analysis using students t–test showed that there is no statistically significant difference between heart rate of the two groups (P>0.05). The mean arterial (MAP) pressure at different time intervals was measured and showed no significant difference (p >0.05). CONCLUSION: A single oral dose of Pregabalin 150mg or Gabapentin 600mg administered one hour prior to surgery are equally effective in reducing hemodynamic response to laryngoscopy and intubation.