Comparison Of Histochemical Characteristics Between Adenocarcinoma Of Endocervical Glands And Intraductal Carcinoma Of Breast

Dr. Ajay J. Shedge; Dr. Shedge Swapna A

Volume : IX, Issue : VII, July - 2019

Comparison Of Histochemical Characteristics Between Adenocarcinoma Of Endocervical Glands And Intraductal Carcinoma Of Breast

Dr. Ajay J. Shedge, Dr. Shedge Swapna A

Abstract :

BACKGROUND: Mucins implicated in cancers of various organs.The apical epithelial surfaces of mammalian respiratory, gastrointestinal, and reproductive tracts are coated by mucus, a mixture of water, ions, glycoproteins, proteins, and lipids.. Mucins are mainly of two types– Neutral and Acidic. Mucus plays an important role in reproductive function and defense of the female reproductive tract. OBJECTIVES: To know and compare the mucin distribution of the adenocarcinoma of endocervical glands and intraductal carcinoma of east. METHODOLOGY: This is a retrospective, observational , analytical, case control study aimed to evaluate mucins histochemical pattern in adenocarcinoma of endocervical glands and intraductal carcinoma of east. Twenty five histologically proven blocks of adenocarcinoma of endocervical glands and intraductal carcinoma of east were taken. Tissue sections were stained by Mayer‘s Haematoxylin and Eosin, PAS, PAS–diastase, Phenylhydrazine–PAS, Alcian blue 2.5, Alcian Blue 1, combined Alcian blue–PAS,Aldehyde Fuschin and combined Aldehyde fuchsin– Alcian blue techniques. RESULTS: Results were tabulated according to color intensity into different grades ranging from + to ++++. Regarding mucin histochemistry of adenocarcinoma of endocervical glands ; a mixture of both neutral and acidic mucins are found. Neutral mucins are in trace amounts. In acidic, no sialomucins but few sulphomucins are seen. In Intraductal carcinoma of east ; ”sialomucins” were seen predominant over neutral and sulphomucins.. CONCLUSION: Mucin histochemical patterns serve as valuable, cost–effective tool in diagnostic histopathology and for the researchers in histology, where a slight change in the mucin pattern may help in the early diagnosis of the disease.