Comparison of intrathecal dexmedetomidine and buprenorphine as adjuvant to 0.5 % hyperbaric bupivacaine in spinal anaesthesia for orthopaedic surgery

AHUJA NEELMANI; SHARMA S.P.; THAKORE NIRDESH; ARORA SAKSHI

Volume : VII, Issue : I, January - 2017

Comparison of intrathecal dexmedetomidine and buprenorphine as adjuvant to 0.5 % hyperbaric bupivacaine in spinal anaesthesia for orthopaedic surgery

Ahuja Neelmani, Sharma S. P. , Thakore Nirdesh, Arora Sakshi

Abstract :

Aims of Study : The aim of the study was to compare intrathecal dexmedetomidine (Group D) and buprenorphine (Group B) in spinal anaesthesia for orthopaedic surgery in terms of onset and duration of sensory and motor block,haemodynamic parameters,post operative analgesia and side effects,if any. Methods : This comparative, randomized ,double blind study was conducted in seventy patients scheduled to undergo elective orthopaedic lower limb surgeries. Group D (n=35) received 15 mg(3 ml) of 0.5% hyperbaric bupivacaine + 5 mcg of dexmedetomidine + Normal saline to make the total volume 3.5 ml while Group B (n=35) received 15 mg(3 ml) of 0.5% hyperbaric bupivacaine + 60 mcg of buprenorphine + Normal saline to make the total volume 3.5 ml. Onset and duration of sensory and motor block, total duration of analgesia,hemodynamic parameters,post operative VAS score, number of rescue analgesics required and adverse effects were noted. Results: There was no significant difference in sensory and motor block onset between 2 groups but significantly prolonged duration of sensory and motor block and post operative duration of analgesia was seen in group D as compared to group B. Significantly reduced number of rescue analgesics were required in group D . Both groups were comparable in terms of hemodynamic parameters and no significant adverse effects were observed in both groups. Conclusion : It was concluded that 5 μg dexmedetomidine as adjuvant to 0.5 % hyperbaric bupivacaine in spinal anesthesia provided prolonged duration of sensory and motor blockade and longer duration of analgesia and stable hemodynamic profile as compared to 60 μg buprenorphine.