COMPARISON OF ORAL PREGABALIN AND PARACETAMOL AS PRE–EMPTIVE ANALGESIC IN PATIENTS UNDERGOING SEPTOPLASTY.

Dr.Vishal; Dr.Prithi Jain

Volume : IX, Issue : VIII, August - 2019

COMPARISON OF ORAL PREGABALIN AND PARACETAMOL AS PRE–EMPTIVE ANALGESIC IN PATIENTS UNDERGOING SEPTOPLASTY.

Dr. Vishal, Dr. Prithi Jain

Abstract :

Effective management of postoperative pain leads to increased patient satisfaction; earlier mobilization and reduced hospital stay. One of the methods used for management of postoperative pain is pre–emptive analgesia –blockade of afferent nerve fiber before surgical stimulus. Aim of this study was to evaluate the efficacy of preemptive Pregabalin and Paracetamol and comparison between the two. Material and methods– The study was a prospective randomized, double blind control study conducted on 60 patients undergoing elective septoplasty surgery under General anesthesia. Patients aged between 18 to 65 years, belonging to ASA class–I and class–II, were divided into 2 groups of 30 patients each. Group A receive 75ug Pregabalin and group B receive 1gm Paracetmol orally 1 hour before induction of anesthesia. Result– Intraoperative heart rate and systolic and diastolic blood pressure, VAS score were compared and it was found to be significantly lower in group A compared to group B.Ramsay sedation score was significantly higher in group A compared to group B until 8 hours post operatively. Conclusion– pre–operative administration of oral Pregabalin 150mg was an effective and a safe adjuvant for acute pain after surgery compared to oral Paracetamol 1000 mg. Pregabalin reduces the postoperative pain score and total analgesic consumption along with sedation and there were no other significant side effects in the postoperative period.