COMPARISON OF POSTOPERATIVE ANALGESIC EFFICACY AND SAFETY OF IV BUTORPHANOL TARTRATE AND IV TRAMADOL HYDRO CHLORIDE IN PATIENTS UNDERGOING MAJOR UPPER ABDOMINAL SURGERIES. A PROSPECTIVE RANDOMIZED DOUBLE BLIND STUDY

Dr.N.Sumathi; Dr.A.Christopher

Volume : IX, Issue : IX, September - 2019

COMPARISON OF POSTOPERATIVE ANALGESIC EFFICACY AND SAFETY OF IV BUTORPHANOL TARTRATE AND IV TRAMADOL HYDRO CHLORIDE IN PATIENTS UNDERGOING MAJOR UPPER ABDOMINAL SURGERIES. A PROSPECTIVE RANDOMIZED DOUBLE BLIND STUDY

Dr. N. Sumathi, Dr. A. Christopher

Abstract :

Background: Butorphanol and Tramadol are synthetic opioid analgesics frequently used for management of post operative pain. Aim: The purpose of this study was to evaluate and compare the post operative analgesic efficacy and side effects of equipotent moderate doses of Butophanol and Tramadol in patients undergoing major surgical procedures. Materials and Methods: This prospective randomized double blind study was carried out on 60 patients belonging ASA grade I & II aged between 18–60 years including either gender, scheduled for elective upper abdominal surgical procedures under general anesthesia. Patients were randomly divided into 2 groups of 30 each. Group B received Butorphanol (2 mg IV) and group T received Tramadol (100mg IV). Anasthesia was standardized in both groups. Study drugs were administered when patient reported pain in the immediate post operative period. The patients were monitored for intensity of pain by visual analogue scale, duration of analgesia, the number of doses required in 24 hours, parameters such as pulse rate, blood pressure, SpO2, Respiratory rate and side effects were noted. Results: Mean duration of analgesia after the first dose of Butorphanaol was 4.24 ± 0.68 hours compared to 5.43 ± 0.32 in Tramadol group. There was significant decrease in pain scores in Butorphanol group compared to tramadol group. This statistically significant decrease in VAS was observed upto 24 hours. The mean number of doses required in 24 hours was 4.1 in group B and 2.6 in tramadol group. Sedation was more in Butorphanaol group, but no patient developed respiratory depression. Side effects such as nausea, and vomiting were more in Tramadol group. Conclusion: Butorphanaol was found to be an effective analgesic than Tramadol. It provides good quality of post operative analgesia with minimum side effects.