COMPARISON OF SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) IN DEGREES CHILD PUGH SIROSIS PATIENTS

Faradilla Nova; Gontar Siregar; Taufik Sungkar

Volume : IX, Issue : II, February - 2019

COMPARISON OF SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) IN DEGREES CHILD PUGH SIROSIS PATIENTS

Faradilla Nova, Gontar Siregar, Taufik Sungkar

Abstract :

Introduction: Liver cirrhosis is a pathological condition that describes the late stages of progressive liver fiosis which is characterized by distortion of the liver architecture, as well as the formation of regenerative nodules. Liver cirrhosis is the most important risk factor in the development of hepatocellular carcinoma.Hepatitis B and C viruses are chronic viral infections that are proven as the etiology of liver cirrhosis and hepatocellular carcinoma. Child–Pugh scores can assess the general condition of patients with cirrhosis and assess multi–organ changes caused by cirrhosis of the liver. VEGF is a key signal used by oxygen–hungry cells to trigger blood vessel growth. VEGF is the main regulator of angiogenesis which works by stimulating mitogenesis from endothelial cells and increasing vascular permeability. Increased VEGF also occurs in the inflammatory process and damage to liver cells. Method:The sample size for each study group are 20 people.The sample were diagnosed with Chirrosis Hepatic. patients were grouped according to the degree of Child Pugh A, B or C and then VEGF serum are perform.To display epidemiological data the subject of research used tabulation to show the descriptive picture. Data analyzed with SPSS 22nd. Result:Based on the anova test, the result showed that VEGF levels were significance highly in the Child Pugh C group than Child Pugh B and A (p – value< 0.05) Conclusion: There is a significant difference in serum VEGF levels between Child Pugh A, B, and C.