COMPARITIVE STUDY OF SERUM ADENOSINE DEAMINASE AND DYSLIPIDEMIA IN TYPE II DIABETES MELLITUS

Dr.K.Venkateswarlu; Dr.U.Sarada; Dr.P.Srirekha; Dr.Sreelatha.D; Dr.P.Laxmi

Volume : V, Issue : II, February - 2015

COMPARITIVE STUDY OF SERUM ADENOSINE DEAMINASE AND DYSLIPIDEMIA IN TYPE II DIABETES MELLITUS

Dr. K. Venkateswarlu, Dr. U. Sarada, Dr. P. Srirekha, Dr. Sreelatha. D, Dr. P. Laxmi

Abstract :

Introduction: Type 2 Diabetes Mellitus is a common metabolic disorder characterized by high plasma glucose levels. Adenosine Deaminase(ADA) is an enzyme which catalyses the irreversible deamination of adenosine to inosine.Adenosine is known to exert potent metabolic effects acting through its receptors.Incresed levels of serum ADA has been shown in individuals with Type 2 Diabetes Mellitus. The study aims to understand the relationship between serum ADA, Lipid profile and blood glucose levels. Objective: To estimate the level of serum adenosine deaminase (ADA), fasting blood glucose and lipid profile in patients with uncomplicated type –2 diabetes mellitus through case control study and also to know any correlation between plasma glucose values with ADA and lipid profile. Method: This study was conducted at Government General Hospital, Kurnool. We took total 50 patients in our study, out of which 25 patients were with uncomplicated type–2 diabetes mellitus and other 25 were as healthy control group. Blood sample were taken and Adenosine deaminase levels were measured calorimetrically, based on the method described by Giusti and Galanti. Other routine investigation like– FBS, PPBS, lipid profile, Blood urea, Serum creatinine were also measured. Results: Elevation of the serum ADP was found in diabetic patients as compared to controls and also strong correlations were found between serum ADA, lipid profile and plasma glucose levels. Conclusions: ADA level is significantly related with the type –2 diabetes mellitus. Any change of ADA level is an indirect expression of tissue adenosine levels. In pathophysiology of diabetes, ADA has its multimetabolic effects.