Concentration of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in the Process of Wound Healing After the Neurosurgery: Preliminary Report

Robert Slusarz; Monika Biercewicz; Beata Haor; Mariola Głowacka; Ewa Barczykowska; Justyna Szrajda; Barbara Ruszkowska-Ciastek; Maciej Sniegocki; Danuta Rosc

Volume : III, Issue : VII, July - 2014

Concentration of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in the Process of Wound Healing After the Neurosurgery: Preliminary Report

Robert Slusarz, Monika Biercewicz, Beata Haor, Mariola G Owacka, Ewa Barczykowska, Justyna Szrajda, Barbara Ruszkowska Ciastek, Maciej Sniegocki, Danuta Rosc

Abstract :

Background. In the process of post surgical wound healing locally secreted relays are involved, including also pro–angiogenic factors, factors of hemostasia or fiinolysis. The function of TAFI in this process is not fully elucidated. The main purpose of this study was to estimate the concentration of thrombin activatable fiinolysis inhibitor in blood serum of the patient with a surgery wound at each measurement before and after the surgery. Methods. The study included 20 adult patients who received a surgical treatment because of degenerative spine changes. The test consisted in three–time determination of TAFI concentration in blood serum of the patients tested. Conclusions. No statistically significant difference in TAFI concentration in blood serum of the tested patients was observed in each measurement before and after the surgery. TAFI concentration in blood serum of the patients operated on differs significantly compared to the control group in measurement one and three.