Convergent One Pot Synthesis of Novel Thiazolo  Pyrimidine and Their Antimicrobial Activities

Monika Bansal; Ramandeep Kaur; Varsha Samdhian; Balbir Kaur

Volume : IV, Issue : I, January - 2014

Convergent One Pot Synthesis of Novel Thiazolo Pyrimidine and Their Antimicrobial Activities

Monika Bansal, Ramandeep Kaur, Varsha Samdhian, Balbir Kaur

Abstract :

One pot three component cyclocondensation of 2-amino-4-phenyl thiazole, ethyl benzoyl acetate and aromatic aldehydes produces Thiazolo Pyrimidine in moderate to good yields. Some of the compounds were screened for anti-bacterial (Staphylococcus aureus, Staphylococcus aureus (MRSA), Streptococcus pyogenes) and antifungal (Aspergillus niger) studies by Agar Diffusion method. Compounds show moderate to good antifungal activity but low antibacterial activity.