Corelation of glycosylated haemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients

Volume : VIII, Issue : IV, April - 2018

Dr Anil Kumar, Dr. Swapnil Gupta, Dr. Suman Lata Verma, Dr Raghavendra Gupta

Objective: To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with

glycosylated hemoglobin (HbA1c).

Methods: Samples were collected from 297 type 2 diabetic patients (aged 19–90 years; male 187, female 110. The sera were analyzed for

HbA1c, total cholesterol (TC), triglycerides (TG), high–density lipoprotein cholesterol (HDL–C and low–density lipoprotein cholesterol (LDLC).

According to the HbA1c level, the patients were divided into three groups, group A (HbA1c <7%, n=170), group B (7%>HbA1c 10%, n=78),

and group C (HbA1c >10%, n=49). The correlation of HbA1c with lipid ratios & individual lipid indexes

were analyzed.

Results: With the increased level of HbA1c, LDL–C had a significantly increasing trend (P<0.05); whereas TC went up with the increased

HbA1c, without any significant differences between three groups. There was no significant correlation between HbA1c and TG or HDL–C.

With the increased level of HbA1c, TC/HDL–C, LDL–C/HDL–C ratios were gradually increased, with significant differences among groups

(P<0.05). The lipid ratios, especially LDL–C/HDL–C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual

lipid.

Conclusions: LDL–C/HDL–C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in

type 2 diabetic patients.