Volume : VIII, Issue : IV, April - 2018
CORRELATION BETWEEN PERIAPICAL CHOLESTEROL, SERUM LOW DENSITY LIPOPROTEINS AND HIGH-SENSITIVITY C REACTIVE PROTEIN LEVELS: A HISTO-BIOCHEMICAL ANALYSIS
Dr. Rekha Mani, Dr. Anilkumar, Dr. Indira. R, Dr. Ranganathan, Dr. Karumaran C S, Dr. T. Vinay Kumar Reddy
Abstract :
Aim
Periapical cholesterol crystals (PCC) have been implicated in refractory periapical pathological processes and untoward healing with a yet unidentified mechanism of cholesterol crystallization. There also exists a knowledge gap regarding the association of PCC with hyperlipidaemia. Recently, studies have proposed a similar mechanism of cholesterol crystallization in periapical region as of atherosclerosis. Thus aim of the present study is to correlate the presence of PCC with levels of established markers of atherosclerosis namely low density lipoproteins (LDL) and high–sensitivity C–reactive protein (hsCRP).
Methods
31 consenting patients of the age group 30 – 65 years, requiring surgical endodontic management were included. Pre–surgically, all patients were advised routine haematological investigations that included a hsCRP assay and LDL test. Subsequently, all patients underwent endodontic treatment followed by periapical curettage. The curetted tissues were subjected to histological examination to detect cholesterol crystals. The existence of cholesterol crystals was correlated with serum values of LDL and hsCRP.
Results
In the present study, patients with PCC neither exhibited elevated LDL nor elevated hsCRP values. Statistical analysis performed using Pearson Correlation Coefficient showed no significant correlation between PCC and serum LDL (p value 0.579) and also between PCC and serum hsCRP (p value 0.540) values.
Conclusion
The correlation between PCC, serum LDL and hsCRP values was insignificant. Authors also propose that mechanism of cholesterol crystallization in periapical lesions may not be similar to that of atherosclerosis as there was no observed elevation of its established markers.
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DOI : 10.36106/ijar
Cite This Article:
Dr. REKHA MANI, Dr. ANILKUMAR, Dr. INDIRA.R, Dr. RANGANATHAN, Dr. KARUMARAN C S, Dr. T.VINAY KUMAR REDDY, CORRELATION BETWEEN PERIAPICAL CHOLESTEROL, SERUM LOW DENSITY LIPOPROTEINS AND HIGH-SENSITIVITY C REACTIVE PROTEIN LEVELS: A HISTO-BIOCHEMICAL ANALYSIS, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-4 | April-2018
Number of Downloads : 325
Dr. REKHA MANI, Dr. ANILKUMAR, Dr. INDIRA.R, Dr. RANGANATHAN, Dr. KARUMARAN C S, Dr. T.VINAY KUMAR REDDY, CORRELATION BETWEEN PERIAPICAL CHOLESTEROL, SERUM LOW DENSITY LIPOPROTEINS AND HIGH-SENSITIVITY C REACTIVE PROTEIN LEVELS: A HISTO-BIOCHEMICAL ANALYSIS, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-4 | April-2018
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