CORRELATION BETWEEN SPOT URINE PROTEIN/CREATININE RATIO WITH 24 HOURS PROTEINURIA IN PRE�ECLAMPTIC WOMEN

Dr. Ruchi Singh; Dr. Krishna Priya Banerjee; Dr. Reena Pant; Dr. Prachi Gupta; Dr. Sarita Mahala

Volume : VI, Issue : VII, July - 2016

CORRELATION BETWEEN SPOT URINE PROTEIN/CREATININE RATIO WITH 24 HOURS PROTEINURIA IN PRE�ECLAMPTIC WOMEN

Dr. Ruchi Singh, Dr. Krishna Priya Banerjee, Dr. Reena Pant, Dr. Prachi Gupta, Dr. Sarita Mahala

Abstract :

Introduction: Appearance of proteinuria remains an important diagnostic criterion of pre–eclampsia. Preeclampsia poses a great hazard to both the mother and the fetus with adverse outcomes, thereby necessitating early detection for proper management. The gold standard test for the diagnosis of significant proteinuria remains the 24–hours urine collection. Because of disadvantages of it, the current study has been designed to evaluate the usefulness of spot urinary protein : creatinine ratio collected before a 24 hour urine collection for diagnosis of significant proteinuria.Materials and Method: 62 pre–eclamptic women with gestational age >20 weeks and with proteinuria +1 or more were studied. First a single voided urine specimen for spot urinary protein: creatinine ratio was taken then 24 hr. urine collection was started. Protein in 24 hr urine was measured by Pirogallol red colorimetric method. In spot urine sample protein was measured by biuret test, and creatinine was measured by modified Jaffe test separately. By these test values protein/creatinine ratio was calculated. Observation and results: With 25–30 years age group, most of our patients were booked(66.13%), middle class(67.74%), hindu(95.16%), form urban areas(67.74%) and literate(79%) and nulliparous(59.68%). 43.55% women were in 29–32 weeks of gestation. 20.97% were in 33–36 weeks and 17.74% patients each were in 24–28 weeks and >36 weeks gestation period. Mean 24 hour urinary protein in our study was 1.5119 ± 1.4107 gm/d. Mean spot sample P:C ratio was 1.6532 ± 1.5662 with Pearson correlation coefficient r=0.979 with p value < 0.0001 showing strong linear coefficient. Conclusion: We conclude that the protein–to–creatinine ratio in spot urine specimens is an accurate, convenient, and reliable method to estimate the protein excretion in urine. In pregnancy induced hypertension, measurement of the protein/creatinine ratio is a simple and inexpensive alternative to 24 hour urine protein estimate for quantitation of proteinuria.