Correlation of CRP and airflow obstruction in predicting cardiac dysfunction with utilization of echocardiography in COPD: prospective observational study in tertiary care setting in India

Sanjay Mundkar; Shital Patil

Volume : VIII, Issue : XII, December - 2018

Correlation of CRP and airflow obstruction in predicting cardiac dysfunction with utilization of echocardiography in COPD: prospective observational study in tertiary care setting in India

Sanjay Mundkar, Shital Patil

Abstract :

Background– COPD will become 3rd leading cause of mortality and 5th leading cause of DALY (disability adjusted life years) worldwide by 2020. Cardiovascular alterations are among the most frequently observed and constitute majority of this morbidity and mortality.

Methods– This is prospective observational study conducted during November 2012 to Feuary 2014, had 50 patients of COPD from the outpatient and indoor of Pulmonary Medicine and Internal Medicine, MIMSR Medical college, Latur India. These patients belonging in majority to moderate (II) and severe (III) GOLD (Global Initiative on obstructive Lung Disease) stages were analyzed by blood profile, BMI, Resting oxygen saturation, CX Ray, Spirometry, ECG and Echocardiography. Main objective was to observe cardiovascular effects in these COPD patients. The statistical analysis was done using Chi Square and Students‘t’ test.

Results:–Maximum patients had Emphysema predominant on CX ray, BMI was low, CRP was raised and were hypoxic, belonged to MMRC grade II and III with low Hemoglobin and Hematocrit. The chief cardiovascular alterations were LVDD (56%), Pulmonary hypertension (48%), Right Ventricular enlargement (46%) and Right atrial enlargement (32%) while LVSD (18%), LA enlargement (10%), LVH (10%) and Cor pulmonale (18%).These changes were significantly associated with the stage of COPD and increasing MMRC grades of dyspnea.

Conclusions:– CRP has definite correlation with airflow obstruction which will be easily assessed by simple spirometry test. Both the parameters will help in predicting cardiac dysfunction by applying electrocardiography and echocardiography, and have positive correlation with it