CORRELATION OF INFILTRATING DUCT CELL CARCINOMA WITH AGE, SITE OF DISTRIBUTION, FREQUENCY WITH MENOPAUSAL STATUS, SIZE, TUMOUR HISTOLOGY, GRADE, LYMPH NODE STATUS AND ER PR, HER2/NEU EXPRESSION

DR ARUNA KUMARI PAGALLA; RACHAKONDA SUHELA

Volume : VII, Issue : VIII, August - 2017

CORRELATION OF INFILTRATING DUCT CELL CARCINOMA WITH AGE, SITE OF DISTRIBUTION, FREQUENCY WITH MENOPAUSAL STATUS, SIZE, TUMOUR HISTOLOGY, GRADE, LYMPH NODE STATUS AND ER PR, HER2/NEU EXPRESSION

Dr Aruna Kumari Pagalla, Rachakonda Suhela

Abstract :

Background: Breast Cancer is the most common malignancy amongst Indian women. Adjuvant therapy, which helps in prolonging survival, is determined by the parameters like age, menopausal status, tumor size, histological type and grade, lymph node status, ER PR HER2/neu on cancer cells.

Aims and objectives: The aim of this study is to look into the association of patient age,menopausal status,laterality,size,histological type, tumor grade and lymph node stage and ER PR HER2/neu expression.

Materials and methods: The study was conducted in the Department of Pathology in CAIMS cancer institute and research center in association with Roche Diagnostics for a period of two years (2014–2016). The sample size is 72. For all specimens of east cancer received by modified radical mastectomy, patient age,menopausal status,laterality,size,histological type, tumor grade as per Nottingham’s Histological score and lymph node stage were recorded and correlated with the ER, PR, HER2/ neu score for each specimen. ER positive tumors were considered to have favourable receptor expression while triple negative followed by ER negative tumors were considered to have unfavourable receptor expression

Results and analysis: This study shows that east cancers are more common in women aged more than 40 years (73.5%),most histological type IDC–NOS, but younger women had more unfavourable receptor expression (61.1%). Grade II tumors (66.2%) were most common but Grade III tumors had more unfavourable receptor expression (90%).N1 lymph node stage (44.1%) was most common but N3 tumors had more unfavourable receptor expression (80%).

Conclusion: Young age, higher tumor grade and higher lymph node stage are associated with more unfavourable receptor expression and adverse prognosis. Hence, early diagnosis of east cancers will help detection at lower tumor grade and stage and improve patient survival.