CORRELATION OF SERUM C-REACTIVE PROTEIN WITH GLYCEMIC STATUS AND LIPID PROFILE IN TYPE 2 DIABETIC SUBJECTS

Shivarajashankara YM; Anil S Baipadithaya; Shivashankara A R

Volume : VIII, Issue : XII, December - 2018

CORRELATION OF SERUM C-REACTIVE PROTEIN WITH GLYCEMIC STATUS AND LIPID PROFILE IN TYPE 2 DIABETIC SUBJECTS

Shivarajashankara Ym, Anil S Baipadithaya, Shivashankara A R

Abstract :

Growing evidence suggests that inflammation plays the key role in the pathogenesis of type 2 diabetes including obesity–related insulin resistance, impaired insulin secretion, and diabetes–related vascular complications. Previous studies have shown that C–reactive protein (CRP), the acute phase reactant and the marker of inflammation is elevated in patients with impaired glucose tolerance and diabetes mellitus. The present study has made an attempt to assess the correlation of serum CRP level with multiple biochemical parameters viz., plasma glucose, glycated hemoglobin, triglycerides, LDL–cholesterol and HDL–cholesterol in type 2 diabetic subjects. Type 2 diabetic subjects (n=102) and healthy controls (n–=114) were the subjects of the study. Levels of fasting plasma glucose (FPG), post–prandial plasma glucose (PPPG), glycated hemoglobin (HbA1c), serum CRP and serum lipids were estimated. Type 2 diabetic patients showed significantly higher levels of FPG, PPPG, HbA1c, total cholesterol, triglycerides, LDL–cholesterol and lower levels of HDL– cholesterol when compared to controls. Serum CRP level had significant positive correlation with FPG, PPPG and HbA1c%. There was no significant correlation of CRP level with serum lipid parameters. The present study demonstrated significant correlation of serum CRP with glycemic status, indicating role of inflammatory marker in diagnosis and management of inflammatory complications in type 2 diabetes mellitus.