Volume : VIII, Issue : IX, September - 2018

Correlation of Serum CEA and CA19–9 levels with ColoRectal cancer in Kashmiri population, a hospital based observational study.

Malik Suhail Ahmad, Tansila Din, Shujat Gul, Azher Mushtaq

Abstract :

Background: . Colon cancer is a complex, multistep cancer in terms of molecular genetics. Colon cancer is believed to be caused by a cascade of genetic mutations leading to progressively disordered local DNA replication and accelerated colonocyte replication. .Several screening tests have been developed to carry diagnosis of colon cancer early, as well as adenomas.

Objectives: To evaluate  the  role of  two important  tumor markers  in  the  diagnosis of  colorectal  cancer,  the  carcinoemyonic antigen (CEA)  and  carbohydrate  antigen  CA19–9.

Materials and methods:The present study was conducted in the department of Surgery of Government Medical College and hospital Srinagar. Total numbers of subjects included were 200 out of which 100 were colorectal cancer patients and 100 healthy subjects visiting Govt. Medical College hospital Srinagar. 7 ml venous blood sample were collected after overnight fasting and serum was analyzed for  CEA& CA– 19–9 by enzyme–linked immunosorbent assay (ELISA).

Observations: The mean age of patients in our study in the two groups was 52.9±10.54 and 48.7±11.04 respectively. The difference being statistically insignificant with a p–value of 0.787. We also observed that CEA levels get significantly raised in patients with colon cancer than in normal patients. The mean CEA levels in patients in our study were 7.3±3.335 while as in the control group was 1.4±0.625. The difference being statistically significant. (p value < 0.001). We also observed in our study that serum CEA levels correlated with the stage of the disease, Mean CEA levels in stageIV disease were 10.12±2.969 as compared to mean levels of 4.63±3.471 in stage II disease. The mean CA19–9 levels in patients with colorectal cancer in our study were 46.73±18.59 compared to 12.72±9.081 in controls. The difference being statistically significant (p–value < 0.001).

Conclusion: Form this study we strongly emphasize that all patients having diagnosed or suspected colorectal cancer should be evaluated with pre–operative serum CEA and Ca19–9 levels.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Malik Suhail Ahmad, Tansila Din, Shujat Gul, Azher Mushtaq, Correlation of Serum CEA and CA19–9 levels with ColoRectal cancer in Kashmiri population, a hospital based observational study., INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-9 | September-2018

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