Correlations Between Changes in Serum Cortisol Level and Biochemical Liver Profile and Adrenal Ultrasound Appearance in Hyperadrenocorticism (Cushing‘s Syndrome) in Dogs

Mario Darius Codreanu

Volume : IV, Issue : V, May - 2014

Correlations Between Changes in Serum Cortisol Level and Biochemical Liver Profile and Adrenal Ultrasound Appearance in Hyperadrenocorticism (Cushing‘s Syndrome) in Dogs

Mario Darius Codreanu

Abstract :

The purpose of this study was to establish an accurate and early diagnosis of hyperadrenocorticism in dogs, expressed mostly by Polyuria–Polydipsia syndrome, dorsal alopecia and abdominal ptosis, in accordance with the additional laboratory biochemical and hormonal changes, in order to establish the most accurate and early stage diagnostic, as algorithms in the screening of adrenal hyperfunction. In all dogs from the study group, the basal cortisol levels revealed a significant increasing, in comparison with normal values. In patients with hyperadrenocorticism, the liver failure was marked and defined by increases (with statistically significant) in serum transaminases and Alkaline Phosphatase activity. Also, in dogs with Cushing`s syndrome, the cholesterol showed a constant and moderate increasing. In order to confirm the diagnostic, to perform a differential diagnostic (between pituitary and peripheral origin) of adrenal changes and to exclude certain diseases with similar symptoms, it was recommended and performed the ultrasound evaluation.