Volume : IX, Issue : IV, April - 2019

CYTOGENETIC AND MOLECULAR STUDIES ON MALE INFERTILITY

Bichu B Sasi, Jijo A J, Sanuj C Breezevilla, Dinesh Roy D

Abstract :

Male infertility is responsible for nearly half of the infertility and affects one man in 20 in general population. Infertility is seen in about 15% of the married couples and about 30–50% of the cases are due to male factors. A large majority of infertile men have associated genetic disorders that range from chromosomal aneuploidy or structural rearrangements to mutations or microdeletions. Precise determination of full range of factors contributing to infertility needs detailed evaluation. Hence the present study was undertaken to evaluate the cytogenetic and molecular aspects of male infertility. Thirty two study subjects with a clinical diagnosis of male infertility were selected as study subjects and twenty subjects without any chronic illness were selected as controls. In this study, Cytokinesis Block Micronuclei (CBMN) assay for quantifying the DNA damage and Karyotyping for chromosome aberrations were performed in each subject. The present study revealed that male infertile subjects showed increased mean CBMN frequency and chromosomal aberrations than healthy controls. Avoid modern lifestyles such as sedentary occupation, habit of alcohol consumption etc and taking precaution about environmental factors such as radiation exposure and temperature at workplace will help to minimize the risk for male infertility. The ideal marriage age, absence of addictions, timely medical assistance can help couples to become pregnant successfully.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

CYTOGENETIC AND MOLECULAR STUDIES ON MALE INFERTILITY, Bichu B Sasi, Jijo A J, Sanuj C Breezevilla, Dinesh Roy D INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-4 | April-2019

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