Delineating the therapeutic effectiveness of allicin on eryptosis during chronic Pb2+ exposure in mice

Avik Sarkar; Dipanjan Bhattacharjee; Dipanwita Sengupta; Soumosish Paul; Kaustav Dutta Chowdhury; Pradip Kumar Sur; Gobinda Chandra Sadhukhan

Volume : V, Issue : V, May - 2015

Delineating the therapeutic effectiveness of allicin on eryptosis during chronic Pb2+ exposure in mice

Avik Sarkar, Dipanjan Bhattacharjee, Dipanwita Sengupta, Soumosish Paul, Kaustav Dutta Chowdhury, Pradip Kumar Sur, Gobinda Chandra Sadhukhan

Abstract :

Chronic Pb2 + intoxication to erythrocytes causes anaemia due to early red cell death which primarily accounts for generation of free radicals followed by waning of antioxidant system and development of oxidative stress. Garlic is a well known plant product which imparts beneficiary effect against different diseases. It is a store house of different active compounds and among which allicin has most potent antioxidant ability and metal scavenging capacity. It also protects the cell against lipoperoxidative damages. In present study, we evaluated the therapeutic efficacy of allicin against erythrocyte death after Pb2 + exposure. Results suggested that allicin treatment in Pb2+ exposed mice exhibited sharp decline in PS exposure and increase in erythrocyte intracellular GSH content followed by downregulation of lipid and protein oxidations. Findings also indicated that allicin has the ability to restore red cell lifespan during chronic Pb2 + exposure.