Volume : V, Issue : III, March - 2015

Delphinidin, a component of pigmented fruits and vegetables may act as an inhibitor of prostate cell carcinoma

Arshi Malik, Adel Al Hazzani, Basiouny El Gamal, Mohamed Abd Ellatif, Sarah Afaq, Waleed N Hassan

Abstract :

Tumor necrosis factor (TNF)–related apoptosis–inducing ligand (TRAIL/Apo2L) is a promising candidate for cancer therapy, however, emergence of drug resistance limits its potential use. Here, we report that Delphinidin the major constituent of pigmented fruits and vegetables, sensitizes TRAIL–resistant LNCaP cells to TRAIL–mediated apoptosis through modulation of apoptotic pathway. When combined with Delphinidin, Apo2L/TRAIL exhibited enhanced apoptotic activity in LNCaP cells characterized by major molecular events. These data might have implications for developing new strategies aimed at eliminating prostate cancer cells resistant to TRAIL.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Arshi Malik, Adel Al Hazzani, Basiouny El Gamal, Mohamed Abd Ellatef, Sarah Afaq, Waleed N Hassan Delphinidin, a component of pigmented fruits and vegetables may act as an inhibitor of prostate cell carcinoma Indian Journal of Applied Research, Vol.5, Issue : 3 March 2015

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