Volume : V, Issue : VII, July - 2015

Detection of Haptoglobin 1, 2 Gene Polymorphisms in Sickle Cell Disease Saudi Children Patients.

Abdulla A. Alharthi

Abstract :

 Background: Sickle cell disease (SCD) is an inherited blood disorder. It is most often found in people with African heritage, but it can also be found in people with ancestry from other parts of the world. To understand this condition, it helps to know more about how your blood is made. Objectives: This study aimed to determine the prevalence of haptoglobin (Hp) 1, 2 gene alleles in Saudi sickle cell disease (SCD) patients. Subjects and methods: Hundred SCD Saudi children patients were included in this study and 50 normal individuals were selected as control group. 5 ml of venous blood was collected from every SCD patient into EDTA test tubes and used to determine the Hp genotyping using a PCR technique followed by agarose gel electrophoresis. Results: The frequency of the Hp–1 allele was 30.8% among SCD Saudi children patients, while the Hp–2 allele predominated with (60.7%). However, the differences were not significant (p 1 0.05) when the allele distributions were compared between SCD Saudi children patients and AA control participants. Conclusions: These findings suggest that the frequency of Hp1 and Hp 2 appears to follow ethnic and geographical distribution.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Abdulla A. Alharthi Detection of Haptoglobin 1, 2 Gene Polymorphisms in Sickle Cell Disease Saudi Children Patients. Indian Journal of Applied Research, Vol.5, Issue : 7 July 2015

Number of Downloads : 430

References :