Detection of inducible and constitutive clindamycin resistance among clinical isolates of Staphylococcus aureus in a tertiary care hospital

Dr Priyanka Kalbhor; Dr Varsha Wanjare; Dr Sunanda Shrikhande

Volume : VIII, Issue : IX, September - 2018

Detection of inducible and constitutive clindamycin resistance among clinical isolates of Staphylococcus aureus in a tertiary care hospital

Dr Priyanka Kalbhor, Dr Varsha Wanjare, Dr Sunanda Shrikhande

Abstract :

Clindamycin is commonly used for treatment of infections caused by S aureus. Routine tests fail to detect inducible clindamycin resistance (ICR) due to erm genes resulting in treatment failure, so there is need to detect this by D–test.

A total of 318 isolates of S aureusfrom were subjected to routine antibiotic sensitivity testing by Kirby Bauer disc diffusion method. ICR was detected by D–zone test as per CLSI guidelines.

Among 318S.aureus isolates, 65(20.44%) isolates were MRSA. ICR was observed in 64(20.13%) isolates, constitutive resistance was found in 43 (13.52%) isolates. Both patterns were higher in MRSA than MSSA. False susceptibility tests may be obtained if staphylococci are not tested for ICR. So,D test should be used for detection of ICR.