DEVELOPMENT AND APLICATION OF NEW HERBAL PESSARIES FOR THE TREATMENT OF SQUAMOUS ENDOCERVICAL METAPLASIA

Orescanin Visnja; Findri Gustek Stefica; Krivak Bolanca Ines

Volume : V, Issue : VI, June - 2015

DEVELOPMENT AND APLICATION OF NEW HERBAL PESSARIES FOR THE TREATMENT OF SQUAMOUS ENDOCERVICAL METAPLASIA

Orescanin Visnja, Findri Gustek Stefica, Krivak Bolanca Ines

Abstract :

The purpose of this work was to test the efficiency of newly developed herbal pessaries for the treatment of the squamous endocervical metaplasia compared to the conventional treatment with albothyl pessaries. The influence of the predictor variables on the outcome of the therapy was also assessed. 192 women in the age range from 20 to 59 years (38.2±8.2) represented experimental group and 30 women ranging from 24 to 59 years (39.4±7.9) represented control group, both diagnosed with squamous endocervical metaplasia were included in the study. The patients from the experimental group were treated locally for 10 days with herbal pessaries containing macerates (Calendula officinalis, Matricaria chamomilla, Lavandula officinalis, Hypericum perforatum L., Achilea millefolium, Thymus serpyllum, Salvia officinalis, Mentha piperita L., Symphytum officinale, Plantago major L., Alchemilla vulgaris) and essential oils (Melaleuca alternifolia, Thymus vulgaris, Pelargonium graveolens, Cympobogon martinii, and Origanum vulgare L.) The patients were treated 10 days with either albothyl (control group) or herbal pessaries (experimental group). New herbal pessaries showed significantly higher efficiency ( =8.39; P=0.0038) in eradication of metaplasia compared to albothyl. Total clearance was observed in 91.15% and 66.67% of the patients in the experimental and control group, respectively. Among the predictor variables, health status of the patients had the highest, statistically significant influence on the outcome of the therapy. The synergistic effect of the medicinal plants with well known wound healing, anti–inflammatory, antimicrobial and antiviral properties could be responsible for high treatment potential of the pessaries. This new product could present good alternative to the conventional treatment of squamous endocervical metaplasia due to high treatment efficiency and no observed side effects during the therapy