Development of a new green protocol for the Biginelli reaction employing readily available catalysts

S. R. Jagtap; B.B. Bahule; R. P. Yadav; Khursheed Ahmad

Volume : IX, Issue : VI, June - 2019

Development of a new green protocol for the Biginelli reaction employing readily available catalysts

S. R. Jagtap, B. B. Bahule, R. P. Yadav, Khursheed Ahmad

Abstract :

A new methodology is designed for the preparation of 1,2,3,4 tetra–hydro pyrimidine derivatives starting from the aromatic aldehyde in combination with ethyl acetoacetate , urea and catalyst like ammonium acetate, cetyl trimethyl ammonium omide and tetra–decyl trimethyl ammonium omide. A three component condensation was carried out in ethanol . The reaction was completed in 1 hour at 80 o C . The products were isolated , purified by column chromatography and characterised by IR and PMR data. The catalysts used arecheaper , easily available and can be recovered, recycled .The pyrimidine derivatives thus obtained are expected to possess some biological activity by the virtue of pyrimidine moiety.