Dexmedetomidine, the ideal drug for attenuating hemodynamic response to laryngoscopy and endotracheal intubation.

Varsha K S; Raghavendra H; Jyothsna; Niranjan

Volume : VII, Issue : VI, June - 2017

Dexmedetomidine, the ideal drug for attenuating hemodynamic response to laryngoscopy and endotracheal intubation.

Varsha K S, Raghavendra H, Jyothsna, Niranjan

Abstract :

To evaluate the efficacy of Dexmedetomidine in the dose of 0.6µg/kg body weight in attenuation of the hemodynamic response to laryngoscopy and endotracheal intubation. MATERIALS AND METHODS: 100 normotensive patients aged 18–50 years old were assigned randomly into two groups control group C and Dexmedetomidine group D. 10 min before induction these two groups received, group C (n=50): received 10 ml normal saline (NS) IV over 10 min, group D (n=50): received dexmedetomidine 0.6µg/kg body weight diluted to 10 ml NS IV over 10 min. After induction of anesthesia, HR, SBP, DBP and MAP were recorded at various time intervals 2nd,5th,8th min before induction and 1st, 3rd, 5th and 10th min after intubation. RESULTS: It was found that in control group there was a significant rise in hemodynamic parameters heart rate(HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure in response to laryngoscopy and endotracheal intubation. There was significant attenuation of hemodynamic response to laryngoscopy and endotracheal intubation in study group who received Dexmedetomidine 0.6 µg/kg body weight 10 minutes before induction (p<0.05). In addition, dexmedetomidine reduced the requirement of thiopentone and produced arousable sedation after extubation without any side effects like adycardia and hypotension (p <0.05). CONCLUSION: Dexmedetomidine (0.6µg/kg) IV given 10 min before induction was seen to effectively attenuate the hemodynamic response to laryngoscopy and tracheal intubation without any side effect.