Dexmedetomidine versus Fentanyl as Pre–medication for Prevention of Adverse Haemodynamic Changes during Laryngoscopy and Endotracheal Intubation.

Dr. J.N. Lakhe; Dr. S.G. Deogaonkar; Dr Anjana Purna Garimella

Volume : VII, Issue : V, May - 2017

Dexmedetomidine versus Fentanyl as Pre–medication for Prevention of Adverse Haemodynamic Changes during Laryngoscopy and Endotracheal Intubation.

Dr. J. N. Lakhe, Dr. S. G. Deogaonkar, Dr Anjana Purna Garimella

Abstract :

BACKGROUND: Laryngoscopy and endotracheal intubation commonly lead to stimulation of sympathoadrenal system giving rise to adverse haemodynamic changes. These may lead to deleterious effects in susceptible patients. One of the approaches to reduce these harmful effects amongst many is the use of premedication like α–2 agonist or opioids. Dexmedetomidine and Fentanyl have been tried successfully towards this end. AIM: This study was carried out to compare the efficacy of Dexmedetomidine versus Fentanyl as premedication in prevention of haemodynamic changes of laryngoscopy and intubation. MATERIAL AND METHODS: 110 patients of both genders and of ASA grade 1 and II, making two groups Group D and F of 55 each. Group D patients received Dexmedetomidine 0.6 µg per kg and Group F received Fentanyl 2µg per kg as premedication given intravenously ten minutes before laryngoscopy. Changes in Heart Rate (HR) and Mean Arterial Pressure (MAP) during laryngoscopy and endotracheal intubation were studied and analysed. CONCLUSION: Dexmedetomidine 0.6µg per kg as premedication proves to be better as compared to Fentanyl 2µg per kg in preventing adverse haemodynamic changes during laryngoscopy and intubation.