DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF PLEURAL FLUID ADENOSINE DEAMINASE ESTIMATION IN RELATION TO PULMONARY TUBERCULOSIS.

Dr. Kamlesh Kumar Swami

Volume : VI, Issue : I, January - 2016

DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF PLEURAL FLUID ADENOSINE DEAMINASE ESTIMATION IN RELATION TO PULMONARY TUBERCULOSIS.

Dr. Kamlesh Kumar Swami

Abstract :

Adenosine deaminase (ADA), an enzyme involved in purine catabolism, catalyses the hydrolytic cleavage of adenosine and 2’deoxyadenosine, irreversible converting them into inosine and 2’deoxyinosine respectively. ADA activity increases during cellular activation for energy demand to detoxify the toxic metabolites. The present study was conducted to evaluate the role of pleural fluid ADA activity in the diagnosis and prognosis of PTB. The pleural fluid ADA values were significantly higher (p<0.001) in all age groups of untreated group as compared to the parallel age groups of the subjects of pulmonary tuberculosis, those were under treatment. Enzyme activity slowly decreases in pleural fluid, during the initial months of treatment phase that indicates fast recovery and good response of anti–tubercular therapy and not stabilized during first 3 months of treatment. Therefore it may be used as a prognostic marker for pulmonary tuberculosis in the initial months of treatment.