Diagnostic value of Adenosine Deaminase (ADA) in Tuberculous Pleural Effusion

Dr.Jayaprakash.B; Dr.Reshmi.S.Nair; Dr.Neena P.S

Volume : VII, Issue : V, May - 2017

Diagnostic value of Adenosine Deaminase (ADA) in Tuberculous Pleural Effusion

Dr. Jayaprakash. B, Dr. Reshmi. S. Nair, Dr. Neena P. S

Abstract :

Tuberculosis is a common cause of pleural effusion in India. Pleural fluid adenosine deaminase (ADA) estimation is a quick test used for the diagnosis of tubercular pleural effusion. The sensitivity and specificity varies in different studies. Aim of study To find out the sensitivity and specificity of ADA in the diagnosis of tuberculous pleural effusion. Methodology The study was done as a diagnostic test evaluation. Total 120 patients, 60 each in TB and nonTB were included. Pleural fluid ADA estimation was done for all patients and the sensitivity and specificity were calculated. Results Pleural fluid ADA level was significantly high in patients with tuberculous pleural effusion. With ADA cut off value of 30U/L the sensitivity was 90% and specificity 83%.Cut off value 42.5U/L sensitivity 80%; specificity 93% and cut off value 70U/L sensitivity 40% and specificity 97%. Conclusion Pleural fluid ADA estimation is a very useful test for the diagnosis of tubercular pleural effusion. As the ADA value increases, specificity increases but sensitivity decreases.