Volume : V, Issue : I, January - 2015

DIFFERENTIALLY REGULATED EXTRACELLULAR GENES EXPRESSION IN PHENYTOIN TREATED ALBINO RAT TESTIS – GENE MICROARRAY ANALYSIS

Rajkumar R, Vathsala Venkatesan

Abstract :

Phenytoin (or diphenylhydantoin) is a primary drug for all types of epilepsy except absence seizures, and in ordinary doses, its anticonvulsant action is without sedation. Many research studies proved that reproductive and sexual dysfunction in male epileptic patients have been attributed to androgen deficiency and also the antiepileptic drugs may alter the release and action of different hormones..The present study is aimed at the effect of phenytoin induced differential regulation Extracellular genes in albino rat testis .The albino rats were divided into two groups ,control and test .The test group was given 120mgs/kg /body weight of phenytoin orally and equal amount of normal saline was given for the control group. After 45 days with the rat under deep anaesthesia ,The testis were removed from the scrotum and stored in liquid nitrogen .The stored specimens of testis of control and tests group were subjected to cDNA microarray analysis. This study showed the differential expression of extracellular genes in test group when compared with the control group.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Rajkumar R,Vathsala Venkatesan Differentially Regulated Extracellular Genes Expression In Phenytoin Treated Albino Rat Testis‾Gene Microarray Analysis Indian Journal of Applied Research, Vol.5, Issue : 1 January 2015

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