DIRECT IMMUNOFLUORESCENCE DECODING THE DIAGNOSTIC DILEMMAS IN DISCOID LUPUS ERYTHEMATOSUS – A STUDY OF 19 CASES.

Dr Deeksha Singh; Dr Shilpi Agarwal; Dr Ram Chander; Dr Kiran Agarwal; Dr Preksha Singh

Volume : VIII, Issue : VIII, August - 2018

DIRECT IMMUNOFLUORESCENCE DECODING THE DIAGNOSTIC DILEMMAS IN DISCOID LUPUS ERYTHEMATOSUS – A STUDY OF 19 CASES.

Dr Deeksha Singh, Dr Shilpi Agarwal, Dr Ram Chander, Dr Kiran Agarwal, Dr Preksha Singh

Abstract :

Background: Discoid lupus erythematosus (DLE) is an autoimmune connective tissue disorder affecting skin. The diagnosis is usually clinical with serologic evidence. However skin biopsy is often needed in early or atypical lesions of DLE. A positive Lupus band test is diagnostic of DLE. Aim: We analyzed direct immunofluorescence findings in skin biopsy in DLE compared to histopathology. Materials & methods: A skin biopsy of lesion was taken from 19 cases of DLE & subjected to histopathogy& DIF examination.Results: The sensitivity of histopathology & DIF for diagnosing DLE was found to be 84.2% each, however combined use of both techniques could diagnose 100% cases. The DIF was particularly helpful in diagnosing 3 histopathologically equivocal cases.