Does bacterial biofilm affect quality of life and prognosis in patients of chronic rhinosinusitis ?

Mathur Navneet; Mahich Sushma; Harshvardhan Rekha; Agarwal Sunita

Volume : X, Issue : I, January - 2020

Does bacterial biofilm affect quality of life and prognosis in patients of chronic rhinosinusitis ?

Mathur Navneet, Mahich Sushma, Harshvardhan Rekha, Agarwal Sunita

Abstract :

Aims: – To assess the presence of bacterial biofilm on the sinus mucosa of chronic rhinosinusitis (CRS) patients and to evaluate the relationship between biofilm and clinical features of CRS. Methods and Material: – It is a prospective study carried out on 100 patients. Samples of diseased paranasal sinus mucosa with CRS who underwent functional endoscopic sinus surgery were analyzed with tube method to detect bacterial biofilm. Results: Bacterial biofilm was observed in 29 out of 50 (58%) disease group cases and 3 out of 50 (6%) control group , (p <0.001).The average Lund Mackay score and symptom score and preoperative Lund Kennedy endoscopic score were significantly higher in biofilm positive than biofilm negative patients. Conclusions: This study demonstrates biofilm, a possible cause for the persistent inflammation, antibiotics resistance and clinical characteristics of CRS patients. Biofilm delays healing process in CRS patients.