Double–Blind Randomised Comparative Study of Dexmedetomidine and Tramadol for Post–Spinal Anaesthesia Shivering

Dr. Vijay Krishnamurthy; Dr. Archana chilakala

Volume : V, Issue : IV, April - 2015

Double–Blind Randomised Comparative Study of Dexmedetomidine and Tramadol for Post–Spinal Anaesthesia Shivering

Dr. Vijay Krishnamurthy, Dr. Archana Chilakala

Abstract :

Background and Aims: Dexmedetomidine (α2 adrenergic agonist) has been used for prevention of post

anaesthesia shivering. Its use for the treatment of post–spinal anaesthesia shivering has not been evaluated. The aim of this study was to evaluate and compare the efficacy, haemodynamic and adverse effects of dexmedetomidine with those of tramadol, when used for control of post–spinal anaesthesia shivering. Methods: A prospective, randomised, and double–blind study was conducted in 50 patients (American Society of Anaesthesiologists

Grade I and II) of either gender, aged between 18 and 65 years, scheduled for various surgical procedures under spinal

anaesthesia. The patients were randomised in two groups of 25 patients each to receive either dexmedetomidine 0.5

μg/kg or tramadol 0.5 mg/kg as a slow intravenous bolus. Grade of shivering, onset of shivering, time for cessation

of shivering, recurrence, response rate, and adverse effects were observed at scheduled intervals. Unpaired t–test was

used for analysing the data. Results: Time taken for cessation of shivering was significantly less with dexmedetomidine

when compared to tramadol. Nausea and vomiting was observed only in tramadol group (28% and; 20% respectively).

There was not much difference in the sedation profile of both the drugs. Conclusion: We conclude that although both

drugs are effective, the time taken for cessation of shivering is less with dexmedetomidine when compared to tramadol. Moreover, dexmedetomidine has negligible adverse effects, whereas tramadol is associated with significant nausea

and vomiting