Effect of abscisic acid on gastric motility in normal and diabetic rats

Shorouk Morshdy; Mohamed Adel; Abeer F. Mostafa; Hanaa Ahmed Hassan Abd El-Moneim

Volume : IX, Issue : X, October - 2019

Effect of abscisic acid on gastric motility in normal and diabetic rats

Shorouk Morshdy, Mohamed Adel, Abeer F. Mostafa, Hanaa Ahmed Hassan Abd El Moneim

Abstract :

Abscisic acid (ABA) is emerging as a new important player in glucose homeostasis. Here, we study its effect on gastric motility in normal and diabetic rats. Forty eight Sprague–Dawley rats were divided into two groups: group I, (Control, n=24), which was subdivided into: subgroup (I a) to determine the effect of ABA in different doses, after adding autonomic drugs (I b), after adding Ca+2 channel blockers (I c), after adding L–NAME (I d), after adding Na+ channel blocker (I e), after adding PPAR –γ antagonist (I f), and group II (Diabetic, n=24), which was subdivided into: subgroup (II a) to determine the effect of ABA in different doses, after adding autonomic drugs (II b), after adding Ca+2 channel blockers (II c), after adding L–NAME (II d), after adding Na+ channel blocker (II e), after adding PPAR –γ antagonist (II f). ABA increased basal gastric motility with higher response in diabetic rats with increased expression of LANCL2 receptors. Also, ABA had excitatory effect after blocking of autonomic receptors. Ca2+ channel blockers diminished the excitatory effect of ABA. Also, ABA led to a significant excitatory effect after adding L–NAME. ABA increased gastric motility after adding lidocaine. The excitatory effect of ABA can be abolished after adding PPAR –γ antagonist.