Effect of Anticancer drugs Cisplatin and 5–Fluorouracil on Collagen Contents in fresh water bivalve, Parreysia corrugata (M).

Mr. Gawali R. D; Dr. Zambare S. P

Volume : V, Issue : I, January - 2015

Effect of Anticancer drugs Cisplatin and 5–Fluorouracil on Collagen Contents in fresh water bivalve, Parreysia corrugata (M).

Mr. Gawali R. D , Dr. Zambare S. P

Abstract :

Cisplatin and 5–Fluorouracil are potent and valuable anticancer drugs widely used for chemotherapy against solid tumors. These drugs exhibits effective chemoprevention in cancer therapy and also lead to several manipulations and cytotoxicity. In present toxicity studies, sub–lethal doses of cisplatin and 5–fluorouracil (LC50/10 for 96 hours) were given to an experimental model, the fresh water bivalve,Parreysiacorrugata for 30 days. TheCollagencontents were estimated from different tissues of control and treated bivalves by using the method of determination of hydroxyproline in tissues as given by Woessner (1961). It was found that collagencontents were decreased in tissues with increase in period of exposure to experimental bivalves. It was also observed that the decrease in amount of collagen content in tissues was more in cisplatin treated bivalves than that of 5– fluorouracil treated bivalves.