Effect of aqueous extract of unripe Musa Paradisica (Banana) skin on cardiac and skeletal muscle of toad

Dr. Rajlaxmi Upadhyay; Dr. Sabita Mohapatra

Volume : X, Issue : VII, July - 2020

Effect of aqueous extract of unripe Musa Paradisica (Banana) skin on cardiac and skeletal muscle of toad

Dr. Rajlaxmi Upadhyay, Dr. Sabita Mohapatra

Abstract :

Objective: Since time immemorial plant and plant products have been used by man to cure his ailments. Banana (Musa Paradisica) and its unripe skin have been in folklore and Ayurvedic medicine as laxative, poultice and anthelmintics. However there are no studies to confirm the pharmacological properties of this indigenous product. The present study was undertaken to evaluate the effect of aqueous extract of banana peel on some isolated muscle preparation of toad. Material and methods: Aqueous extract of banana skin was prepared and its effect on isolated rectus abdominis muscle and heart of toad was studied. The extract was used in increasing doses along with known agonist and antagonist. The study was done in two parts to see the effect on • Cardiac muscle • Skeletal muscle Results: Effect on cardiac muscle: In lower doses toad heart showed increase in heart rate and amplitude of contraction, and heart was inhibited by the extract in higher doses, which was partially antagonised by atropine. In presence of propranolol though there is significant decrease in heart rate by the extract, the decreased in the force of contraction was not statistically significant. Nifedipine produced significant decreased of heart rate and amplitude of contraction of the extract Effect on skeletal muscle: The extract produced a graded stimulatory response with different doses on acetylcholine induced contraction. Neostigmine further increased the stimulatory effect. At lower concentration, the extract potentiated acetylcholine induced contractions which was partially blocked by standard antagonist pancuronium Conclusion: Aqueous extract of raw banana skin has a stimulatory effect on cardiac muscle of toad like digitalis and also skeletal muscle potentiation action like neostigmine. Further studies are required to establish the usefulness of active principles involved in banana skin extract