Volume : IV, Issue : II, February - 2014

Effect of Artesunate on Atherosclerosis in Experimentally Induced Nephrotic Syndrome in Rats

Amal A. Hassanin, Ahmed Shata

Abstract :

OBJECTIVES : This study tested the effect of Artesunate on atherosclerosis in experimentally Induced Nephrotic syndrome in rats.

METHODS& RESULTS: 40 male Sprague-Dawley rats were randomly divided into two main groups: Group I: 10 rats served as control group and Group II: Nephrotic group in which nephrosis was induced by subcutaneous injection of HgCl2 (1mg/kg) on days 0, 2, 4, 7, 9 and 11.This group was further subdivided into 3 equal subgroups as follow: II-A: Nephrotic group Without treatment. II-B: Nephrotic group, received 10 mg/kg telmisartan daily intragastrically for 4 weeks II-C: Nephrotic group, received intraperitoneally administration of 5 mg/kg artesunate given every day for 5 days (5 injections), then every 2 day intervals (9 injections) for 4 weeks.

Artesunate decreased inflammatory markers of atherosclerosis in HgCl2-induced nephrotic syndrome rats; such as C-RP and TNF-α.

CONCLUSION: artesunate can ameliorate atherosclerosis through modulation of lipid disorders and inflammatory markers as C-RP and TNF-α , that culminate in improvement of nephritic syndrome. Howevere, telmisartan excerts its effect through its effect on lipid parameters and inflammatory markers as TNF-α only.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Amal A.Hassanin, Ahmed shata Effect of Artesunate on Atherosclerosis in Experimentally Induced Nephrotic Syndrome in Rats Indian Journal of Applied Research, Vol.IV, Issue. II

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