EFFECT OF CILNIDIPINE VERSUS LOSARTAN ON LIPID PROFILE IN PATIENTS OF HYPERTENSION WITH OR WITHOUT DIABETES

Mayuri K. Bhalerao; Saroj Kothari

Volume : VIII, Issue : V, May - 2018

EFFECT OF CILNIDIPINE VERSUS LOSARTAN ON LIPID PROFILE IN PATIENTS OF HYPERTENSION WITH OR WITHOUT DIABETES

Mayuri K. Bhalerao, Saroj Kothari

Abstract :

Introduction: With the presence of the beneficial effects unlike other calcium channel blockers, status of cilnidipine over losartan on lipid profile (LP) of hypertensive patients with or without type 2 diabetes mellitus (DM) is yet to be established.

Aim: To investigate the comparison between cilnidipine and losartan with respect to changes in LP in hypertensive patients with or without DM.

Methods and materials: We conducted a longitudinal, prospective, open labelled, comparative clinical study. Of 161 enrolled hypertensives, 130 completed the study with follow up over a period of one year. Group I (n=34); and Group III (n = 32) patients with type 2 DM received cilnidipine 10–20mg orally OD. Group II (n =33); and Group IV (n = 31) patients with type 2 DM received losartan 50–100mg orally OD. HDL–C, LDL–C & TC; and TGs were assessed at the start and at the end of the study.

Statistical Analysis: Using the one–tailed paired Student’s t–test.

Results: Post–treatment, both cilnidipine treated groups, showed significant increase in the HDL – C levels (group I from 46.55±8.21 to 48.91±9.02, p value = 0.000 and group III from 51.48±7.34 to 54.40±7.65, p value = 0.000) while losartan treated groups showed significant decrease in TC levels (group II from 205.83±37.67 to 204.99±37.67, p value = 0.035 and group IV 226.1±44.1 to 224.97±44.91, p value =0.030) at the end of 12 weeks of therapy. However, on inter–group comparison, there were no significant differences in HDL–C, LDL–C, TC and TGs between the cilnidipine and losartan groups.

Conclusion: The present study demonstrated that cilnidipine can be recommended as an alternative anti–hypertensive, may be more useful for patients of hypertension with or without diabetes mellitus from its effects on lipid metabolism.