Effect of Cisplatin and 5–Fluorouracil on Total Protein Contents in Fresh Water Bivalve Parreysia Corrugata.

Mr. Gawali R.D.; Dr. Zambare S.P

Volume : V, Issue : I, January - 2015

Effect of Cisplatin and 5–Fluorouracil on Total Protein Contents in Fresh Water Bivalve Parreysia Corrugata.

Mr. Gawali R. D. , Dr. Zambare S. P

Abstract :

Cisplatin and 5–Fluorouracil are potent and valuable anticancer drugs widely used for chemotherapy against solid tumors. These drugs exhibits effective chemoprevention in cancer therapy and also lead to several manipulations and cytotoxicity. In present toxicity studies, sub–lethal doses of cisplatin and 5–fluorouracil (LC50/10 for 96 hours) were given to an experimental model, the fresh water bivalve Parreysia corrugata for 30 days. The total protein contents were estimated from different tissues of control and treated bivalves by Lowry’s method. It was found that the total protein contents were decreased in tissues of experimental bivalves with increase in period of exposure to these anticancer drugs. It was also observed that the decrease in amount of total protein content in tissues was more in cisplatin treated bivalves than that of 5– fluorouracil treated bivalves.