Effect of Diabetes Mellitus type 2 on Pulmonary Function Tests- A Prospective Clinical Study

Manish Dudhani; O P Jatav; Jitendra Agrawal

Volume : VIII, Issue : XII, December - 2018

Effect of Diabetes Mellitus type 2 on Pulmonary Function Tests- A Prospective Clinical Study

Manish Dudhani, O P Jatav, Jitendra Agrawal

Abstract :

Background & objective: The aim of this study was to assess pulmonary functions in patients with type 2 diabetes mellitus and to determine any correlation between type 2 diabetes mellitus and pulmonary functions.

Materials & methods: Sixty diabetic and thirty Non diabetic were selected by random sampling. Detailed anthropometric and physiological data were collected, spirometry was performed and Forced vital capacity (FVC), Forced expiratory volume in 1 second(FEV1), FEV1/FVC, Peak expiratory flow rate ( PEFR), forced expiratory flow (FEF 25 –75%) were measured. Results were analyzed by calculating Mean ± SD, using Student‟s t test and Anova test by SPSS statistical software.

Results: From the above study we see that all the respiratory parameters are reduced in study group compared to control group. FEV1, FVC, FEV1/FVC, PEFR and FEF 25–75% are significantly reduced. (p value < 0.01)The study also shows that the respiratory parameters are inversely related with glycemic status and duration of Diabetes mellitus. There was reduction in dynamic lung function variables. There was a mixed pattern (restrictive and obstructive) of involvement in lung functions.

Conclusion: The present study showed reduction in Mean FVC% and mean FEV₁% were significantly reduced in cases group as compared to controls. PFT parameters were also significantly correlated with microvascular complications namely neuropathy, nephropathy and retinopathy. An inverse association was found between PFT parameters and duration of diabetes mellitus and poor glycemic control