EFFECT OF HYPERBILIRUBINEMIA ON RENAL FUNCTION IN CASES OF ACUTE HEPATITIS A

Dr.SnehaWadalkar; Dr.A.D.Deepak; Dr.ParineetaSamant; Dr.SantoshGawali; Dr.Vinita Singh

Volume : V, Issue : IX, September - 2015

EFFECT OF HYPERBILIRUBINEMIA ON RENAL FUNCTION IN CASES OF ACUTE HEPATITIS A

Dr. Snehawadalkar, Dr. A. D. Deepak, Dr. Parineetasamant, Dr. Santoshgawali, Dr. Vinita Singh

Abstract :

Acute hepatitis A is a self limiting infectious disease. Inspite of rare Extrahepatic manifestations, cases of acute renal failure are reported. Awareness of the potential renal involvement in hepatitis virus infection has become a need. | AIM : To co–relate serum levels of Total Bilirubin with Renal parameters in Acute hepatitis A patients. | METHODLOGY: Blood samples of 40 diagnosed Acute Hepatitis A patients, within age group of 30–60 yrs were collected on day1, day6 and day12 of hospitalization and analysed for liver and renal profile. Results were compared and co–related statistically. | RESULT: Serum total bilirubin (14.7+1.11 mg/dl) was increased on day 1 which decreased on day6 (13.8+1.99 mg/dl); with significant decrease on day12 (12.8+0.34 mg/dl, p<0.0001). On day6 Serum Creatinine (5.6+0.51) and BUN (119 ±12.4mg/dl, p < 0.0001) showed statistically significant increase. Total Bilirubin showed strong positive correlation with Creatinine (r=0.675) and BUN (r=0.955) on day6. | CONCLUSION: Hyperbilirubinemia may be considered as one of the cause of functional renal impairment in Acute Hepatitis A infection.