EFFECT OF METHANOLIC EXTRACT OF PIPER CUBEBA LINN. FRUITS ON THE PHARMACODYNAMICS OF PIOGLITAZONE IN ALLOXAN INDUCED DIABETIC RATS.

Mohammed Gayasuddin Mouid; Shakil Sait.S; Kavimani.S

Volume : VI, Issue : II, February - 2016

EFFECT OF METHANOLIC EXTRACT OF PIPER CUBEBA LINN. FRUITS ON THE PHARMACODYNAMICS OF PIOGLITAZONE IN ALLOXAN INDUCED DIABETIC RATS.

Mohammed Gayasuddin Mouid, Shakil Sait. S, Kavimani. S

Abstract :

The present study was aimed to find out the effect of multiple dose (7days) treatment of methanolic extract of Piper cubeba Linn. Fruits (MeOHPCLF) on the hypoglycemic activity of Pioglitazone in diabetic rats. Herb–Drug interaction about Oral antidiabetic drugs is a challenging concept, since the consumption of food and other herbal drugs is not documented in diabetic patients’ profile. Albino female wistar rats were divided into 4 groups of 6 animals each and made diabetic by administering Alloxan Monohydrate at a dose of 150mg/kg. Animals of group –II (Extract treated group) were administered orally with the extract at a dose of 400mg/kg for 7 days and Animals of group –IV (Test group) were administered orally with the extract at a dose of 400mg/kg for 7 days followed by fasting overnight on the seventh day and were orally administered with Pioglitazone at a dose of 10mg/kg on 8th day. All the 4 groups were tested with intraperitoneal glucose tolerance test (IPGTT) by administering glucose (2.5%) intraperitoneally and decrease in blood glucose concentration was determined in each group by GOD–POD method. MeOHPCLF enhanced the activity of Pioglitazone and significantly lowered Blood glucose concentration in MeOHPCLF + Pioglitazone treated group .Hence MeOHPCLF enhances the activity of Pioglitazone .