Effect Of Non-Surgical Periodontal Therapy On Clinical Parameters And Human Cytomegalovirus (HCMV), Epstein -Barr Virus (EBV) And Herpes Simplex Virus (HSV-1)

Dr. Akta H.Sanghavi; Dr. Tulsi H.Sanghavi; Dr. Dipak Dave

Volume : X, Issue : VI, June - 2020

Effect Of Non-Surgical Periodontal Therapy On Clinical Parameters And Human Cytomegalovirus (HCMV), Epstein -Barr Virus (EBV) And Herpes Simplex Virus (HSV-1)

Dr. Akta H. Sanghavi, Dr. Tulsi H. Sanghavi, Dr. Dipak Dave

Abstract :

Introduction: Periodontitis is multifactorial, chronic disease. Before 1970s, periodontitis was believed to be caused by bacterial plaque. After evolution in microbiology, 8 herpes viruses infection identified in humans. Among these human herpes virus, studies reported the presence of cytomegalovirus, Epstein–barr virus and herpes simplex virus more frequently in periodontitis patients than others. The aim of this interventional study was to compare clinical parameters and to quantify the human herpes viruses like Human cytomegalovirus (HCMV), Epstein – Barr virus (EBV) & herpes simplex virus (HSV–1) in chronic periodontitis patients before and at 3 months following non–surgical periodontal therapy by using multiplex PCR method. Materials and methods: This multiplex PCR method quantified the herpes viruses. Subgingival plaque samples were collected from 32 chronic periodontitis patients. Oral hygiene index – simplified, gingival index and probing depth were measured. Recording of clinical parameters and microbial analysis was carried out at baseline and at 3 months following the non–surgical periodontal therapy. Results: Statistically significant improvement found in all clinical parameters with statistically significant reduction in quantity of herpes viruses at 3 months following therapy. Conclusion: This study demonstrated that treatment of chronic periodontitis by non–surgical periodontal therapy result in improvement in clinical parameters and reduction in quantity of herpes simplex virus – 1, Epstein – barr virus and human cytomegalovirus