Effect of Plumbago zeylanica ethyl acetate extract in prevention or treatment of arthritis using adjuvant induced arthritic rat model

Dr. Aparanji Poosarla

Volume : VII, Issue : XI, November - 2017

Effect of Plumbago zeylanica ethyl acetate extract in prevention or treatment of arthritis using adjuvant induced arthritic rat model

Dr. Aparanji Poosarla

Abstract :

PZE–6, a freeze dried ethyl acetate fraction, purified from the roots of Plumbago zeylanica, its anti–inflammatory and anti–arthritic effects on disease development was assessed in comparison with indomethacin and cyclophosphamide in rats with adjuvant–induced arthritis (AIA). PZE–6 fraction significantly suppressed the arthritis by decreasing clinical score and delayed type hypersensitivity response (DTH). Normalized hematological parameters were also observed after the treatment with PZE–6 in AIA rats. In addition, we have conducted experiments to investigate the effect of PZE–6 on the prevention of adjuvant induced arthritis and simultaneously determined its effect on established AIA.