Effect of SMOF lipid emulsion on pro inflammatory cytokines and oxidative stress markers in sepsis patient`

Jadhav TS; Badade ZG; Vyas NL; Ingale Atul; More Kavita; Pande Bhupendra; Pramitkumar

Volume : IV, Issue : IX, September - 2014

Effect of SMOF lipid emulsion on pro inflammatory cytokines and oxidative stress markers in sepsis patient`

Jadhav Ts, Badade Zg, Vyas Nl, Ingale Atul, More Kavita, Pande Bhupendra, Pramitkumar

Abstract :

Sepsis is the systemic inflammatory response to infection and remains primary cause of death from infection. Cytokines and oxidative stress (OS) has main role in the pathophysiology of sepsis. Recently there has been increased interest in the lipid component of parenteral nutrition, which promises to modulate inflammatory responses and improve the outcome of patient with immune–mediated conditions. Aims and objectives: The present study is aimed to evaluate effect of parenteral lipid emulsion (SMOF) on oxidative stress and pro–inflammatory markers in sepsis – pre and post infusion and correlation between them. Methodology: The study comprised of 40 sepsis patients, received SMOF lipid emulsion. Blood Samples were collected from septic patient; pre and post (after 48 and 96 hrs) on initiation of lipid emulsion. The pro–inflammatory markers IL–6, IL–8 and CRP and oxidative stress markers (MDA, NO•, SOD, CAT and Vitamin C) were estimated pre and post infusion. Results: Levels of MDA, NO•, SOD, CAT and inflammatory markers IL–6, IL–8 and CRP were significantly decreased and vitamin C significantly increased on infusion of SMOF. Conclusion: Present study suggests that SMOF infusion decreases the accumulation of toxic radicals i.e. lipid peroxidation products, pro–inflammatory response and increases the concentrations of antioxidants, which boost the immunity of the patient, which in turn decreases the severity of the sepsis.