Volume : V, Issue : II, February - 2015

Effect of Tamoxifen on Visual Pathway of Human and Wistar Rat using Visual Evoked Potential

Khoshnoud H. , Shushtarian S. M

Abstract :

Aim: Tamoxifen is a drug which is used for treatment of east cancer. Beside its advantages for east cancer treatment, it has certain side effects. The aim of present study is to search for its side effects on visual pathway both in human and animal groups using visual evoked potential. Method: Twenty five female patients with tamoxifen treatment for east cancer were selected for the purpose of recent work. Along with human population twenty wistar rats were taken as an animal group. The animal group were divided in four A, B, C and D groups. Four doses i.e. 2, 4, 8,16 mg of tamoxifen were injected in A, B, C and D groups respectively. For both groups i.e. human and animal group a suitable control group was selected. Visual evoked potential was tested for all subjects either human or animal group. Latency (msec) of VEP, P100 peak was measured in total cases. SPSS version 13 software program was used to analyze the data obtained. Result: It was found out that 40% of human population in human group & C & D of animal groups had abnormal VEP which reflect it self in delay of VEP, P100 peak. Conclusion: From the results of present work one can conclude that tamoxifen certainly has adverse effect on visual pathway which can be proved by VEP examination but in this respect dose of tamoxifen is important which will be discussed in detail in full paper.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Khoshnoud H., Shushtarian S.M Effect of Tamoxifen on Visual Pathway of Human and Wistar Rat using Visual Evoked Potential Indian Journal of Applied Research, Vol.5, Issue : 2 February 2015

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