EFFECT OF THYROID HORMONE REPLACEMENT IN CHRONIC KIDNEY DISEASE PATIENTS WITH HYPOTHYROIDISM

Siva Kalyani Jyotula; B Vivekanand; A Mythili; Jayanthy Ramesh; Dr K A V Subrahmanyam

Volume : IX, Issue : VI, June - 2019

EFFECT OF THYROID HORMONE REPLACEMENT IN CHRONIC KIDNEY DISEASE PATIENTS WITH HYPOTHYROIDISM

Siva Kalyani Jyotula, B Vivekanand, A Mythili, Jayanthy Ramesh, Dr K A V Subrahmanyam

Abstract :

Context: There is a lack of data on whether treatment of subclinical hypothyroidism will improve estimated glomerular filtration rate (eGFR) in CKD. Aim: To study the effect of thyroid hormone replacement on the progression of CKD. Materials and Methods: A prospective cohort study was done on 180 CKD patients attending a tertiary care hospital in South India, who were screened for primary hypothyroidism and the hypothyroid patients were started on Thyroid Hormone Replacement (THR). Three months after achieving the target TSH, reassessment of eGFR was done. Results: Out of the 180 patients, 12.2% had primary hypothyroidism among whom, 11.1% had subclinical hypothyroidism and 1.1% had overt hypothyroidism. There were 3 (13.63%) hypothyroid cases in stage 3A, 5 (22.72%) in stage 3B, 12 (54.54) in stage 4 and 2 (9.09%) in stage 5. The mean eGFR has increased from 26.36 10.82 ml/min/1.73 m2 at baseline to 33.85 15.35 ml/min/1.73 m2 3 months after THR. Conclusions: Primary hypothyroidism, especially subclinical hypothyroidism is commonly associated with CKD. THR significantly improved the renal function