Effect of Triptolide on Vital Organs, Blood  Biochemical Parameters and Histomorphology of  Testis in Male Bandicota Bengalensis

Parul Dhar; Neena Singla; Bhupinder Kaur Babbar

Volume : IV, Issue : II, February - 2014

Effect of Triptolide on Vital Organs, Blood Biochemical Parameters and Histomorphology of Testis in Male Bandicota Bengalensis

Parul Dhar, Neena Singla, Bhupinder Kaur Babbar

Abstract :

Present study reports the effect of triptolide in male Bandicota bengalensis. One group of rats was kept as vehicle control and the other three groups were fed on bait containing 0.15, 0.2 and 0.25% triptolide. Autopsy of rats immediately after 15 days of treatment period revealed no significant effect on weights of vital organs. A significant (P ≤ 0.05) increase in plasma levels of total proteins, alkaline and acid phosphatases and alanine and aspartate aminotransferases in response to stress induced by triptolide was observed in treated groups of rats. A significant (P ≤ 0.05) effect of treatment was also observed on histomorphology of testis in the form of decrease in seminiferous tubule diameter and number of various spermatogenic cells. Giant cells containing several round nuclei within a single cytoplasmic boundary were also observed in treated rats. Present studies suggest the antifertility potential of triptolide against male B. bengalensis.