EFFECTS OF CARVEDILOL IN LEFT VENTRICULAR DYSFUNCTION IN PATIENTS WITH HEART FAILURE

V Shravya; Ch Chandana; B Siva Subrahmanyam; E Venkateshwarlu; BS Sharvana Bhava

Volume : IX, Issue : VII, July - 2019

EFFECTS OF CARVEDILOL IN LEFT VENTRICULAR DYSFUNCTION IN PATIENTS WITH HEART FAILURE

V Shravya, Ch Chandana, B Siva Subrahmanyam, E Venkateshwarlu, Bs Sharvana Bhava

Abstract :

Back ground: we conducted single center single drug study designed to establish the efficacy and safety of Carvedilol, a beta blocker of third generation which have vasodilator properties, in chronic heart failure. Methods: 50 patients with heart failure were treated with Carvedilol, and echocardiographic evaluation was performed at the start and after 6 months. Results: Ejection fraction, blood pressure, pulse rate were improved in patients after 6 months treatment compared to before start of treatment with carvedilol. we found significant differences in :systolic blood pressure(p value 0.0479);diastolic blood pressure (p value 0.2455);ejection fraction(p value 0.2691); pulse rate(p value 0.2192).Conclusion: From this study we conclude that Carvedilol have proved to have good efficacy on the ejection fraction in patients with left ventricular dysfunction despite of few limitations like small sample size. Therapy of several months is required for improvement of ejection fraction, as these changes do not occur in the short term.